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Production process of kojic acid

China kojic acid production began in the 1990 s, more general production process is: the starch or glucose to fermentation, filtering to evaporation concentration, crystallization to the crystallization mother liquor, once again evaporation concentration and the secondary crystallization, a crystallization of crystal and the secondary crystallization of crystal after mixing to dissolve, decoloring and recrystallization - drying - finished products;The mother liquor of secondary crystallization is abandoned.

The above general process is simple, but there are some shortcomings:

1. The use of steam evaporation concentration temperature is high, affecting the color of the product;

2. The filtered fermentation broth contains a certain amount of residual sugar, protein and colloid, which will affect the quality of the product;

3. The crystal mother liquor can be used twice at most. If the number of times is more than twice, the product produced is unqualified due to high impurity content.Therefore, the mother liquor after secondary crystallization must be discarded, there is a certain environmental pressure;

4, there is no effective removal of metal ions in the solution, because the complex ability of kojic acid is very strong, can form a complex with a variety of metal ions, these complexes will be due to the complexation of different ions make kojic acid with different colors.For example, when iron ions are complexed with koic acid, they take on a red color. When copper ions are complexed, they take on a green color.Some factories add metal ion masking agents (such as EDTA) to make the color of kojic acid look better.

Kojic acid of our company adopts proprietary technology developed by ourselves, which not only overcomes the above disadvantages, but also has the following advantages:

1. The production process is carried out at normal temperature (no high-temperature steam evaporation and concentration is used). Because kojic acid is very sensitive to temperature in the production process, the color of the product is better by normal temperature production;

2. Added the process of removing metal ions to make our kojic acid more white;

3. never add metal ion masking agent in the production process, the product color is natural color.4. The impurity removal process is added, and the crystal mother liquor is recycled without environmental protection pressure.

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Raw material of kojic acid production, whether for animal products

The main raw materials of kojic acid are glucose and yeast paste.

The company's glucose selected domestic well-known manufacturers using non-transgenic corn production of glucose.The process of glucose production is as follows: corn starch USES amylase for liquefaction, then USES glycosylase for saccharification, crystallization and drying.

The raw material of yeast paste is yeast or beer yeast for fermentation, which is concentrated into finished products after enzymatic hydrolysis.

All raw materials of kojic acid of our company are not made with any animal or blood products.

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Whether the mesh number of kojic acid crystal is as small as possible

For the chemical process, the crystallization process is a purification process, the crystallization process has the characteristics of exclusivity, only similar substances can be crystallized together.The larger the crystallization, the higher the purity of the product.At the same time, after crystallization is completed, the crystal washing process is also very important.Impurities in the crystal stock will adhere to the crystal surface, and the impurities on the surface will be removed by washing.

Kojic acid solubility is good, in the preparation of cosmetics, the need to dissolve kojic acid.Therefore, the number of kojic acid is not as small as possible.Generally speaking, judging from meat, the larger and more orderly the crystal shape of kojic acid, the higher the quality of kojic acid.

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Which is the best color of kojic acid

The color of kojic acid must be as white as possible.For pure kojic acid, kojic acid is a white needle-like crystal.Due to the strong complexation ability of kojic acid (also known as "chelation"), it can form complexes with various metal ions, and these complexes can give kojic acid different colors depending on the ions in the complexation.For example, when iron ions are complexed with koic acid, they take on a red color. When copper ions are complexed, they take on a green color.The quality of kojic acid can be judged by its color.

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How stable is kojic acid

Kojic acid stored in a cool dry place away from light, effective up to three years.

According to relevant literature reports, the content of kojic acid in kojic acid cream products is reduced to 90% after 185 days and 50%, after 1200 days without treatment.

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Does kojic acid need commodity inspection

Our kojic acid is an intermediate, not a consumer product. There is no need of inspection at the time of export.

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How to identify rhEGF?

At present, there are many kinds of epidermal growth factors on the market, such as recombinant human epidermal growth factor, recombinant mouse epidermal growth factor, recombinant bovine epidermal growth factor and so on.Our product is recombinant human epidermal growth factor.The way to identify different growth factors is to look at the n-terminal amino acid sequence of the factor, different factors, the n-terminal amino acid sequence is different.

The n-terminal amino acid sequence of our recombinant human epidermal growth factor is as follows:

Asn-Ser-Asp-Ser-Glu_cys_Pro-Leu-Ser-His-Asp-Gly-Tyr-Cys-Leu

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What are rhEGF's main production materials? Are they animal products?

The main raw material of recombinant human epidermal growth factor is pharmaceutical grade glucose.

The company's glucose selected domestic well-known manufacturers using non-transgenic corn production of glucose.The process of glucose production is as follows: corn starch USES amylase for liquefaction, then USES glycosylase for saccharification, crystallization and drying.Each batch of purchased raw materials has a formal non-gmo certificate.

All of our growth factor raw materials are not made from any animal or blood products.

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Why do other similar products have full bottles instead of full bottles?

The recombinant human epidermal growth factor is treated with a filler (also known as a dispersant) during freeze-drying.For 0.1mg, 1mg and 10mg packages, 3ml ampere bottles were used.This is illustrated by 10mg:

The total volume of 10mg of growth factors was only 0.01ml, and when loaded into a 3ml ampere flask, its volume accounted for only 0.33% of the bottle space.If you do not add filler, just enough to adhere to the surface of the bottle, the naked eye can hardly see.Therefore, only fillers were added to disperse growth factors in the fillers.What we see on the outside are fillers.

The role of fillers is to disperse, dissolve easily and be visually visible, but the fillers are not the product itself, and the more you add, the better.In our 3ml ampere flask, the filling amount of the filler is 1 g, which, from the appearance, accounts for one third of the bottle's capacity.

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How is freeze-dried powder stored?

If it is freeze-dried powder, it is recommended to store it in the refrigerator at the storage temperature of 2~8°C, The maximum storage time is 3 years. If the solution has been prepared, store it in the refrigerator at a temperature of 2~8°C, It is recommended to use it within 15 days.

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Can you provide liquid growth factors?

Yes. However, there are more restrictive factors, and the packaging and transportation costs are higher.

The liquid growth factor solution is concentrated EGF solution, which is packaged in a sterilized soft bottle. The refrigerated box with refrigerating source is needed in the transportation process, and the packaging cost and transportation cost are relatively higher. It is not recommended to buy solutions except in special cases.

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Does transportation affect factor activity?

EGF freeze-dried powder is generally transported by express. The temperature in the transportation process is normal temperature, and the transportation time is usually only a few days. At this temperature and time, the effect on the activity of the factor is small.

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